Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand

Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand

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Canine parvovirus type 2 (CPV-2) is responsible for hemorrhagic gastroenteritis in dogs worldwide.High genomic substitution rates in CPV-2 contribute to the progressive emergence of novel variants with increased ability to evade the host immune response.Three studies have analyzed the genomic mutations of CPV-2 variants in Thailand.These investigations were independently conducted at different timepoints.

Thus, a retrospective integrated analysis of CPV-2 genomic mutations has not been fully performed.Our study aimed at evaluating the evolutionary changes in CPV-2 in Thailand from 2003 miller multimatic 255 tig kit to 2019.Two hundred and sixty-eight Thai CPV-2 nucleotide sequences were used for multiple amino acid sequence alignment and phylogenetic analyses.From 2003 to 2010, CPV-2a and -2b were the only variants detected.

CPV-2c, emerged in 2014, replacing CPV-2a and -2b, and has become a major variant in 2019.Phylogenetic analysis revealed that the proposed mutation pattern of VP2 amino acid residues could help distinguish Thai CPV-2 variants.This comprehensive examination provides insight into the genomic evolution of CPV-2 in Thailand since its where to buy powdered food coloring first reporting in 2003, which may facilitate the surveillance of the potential genetic alteration of emergent CPV-2 variants.